| 降脂宁肝胶囊治疗大鼠脂肪肝的实验研究 |
| |
| 引用本文： | 杨钦河,杨环文,谢芳,张玉佩.降脂宁肝胶囊治疗大鼠脂肪肝的实验研究[J].辽宁中医杂志,2008,35(9):1420-1422. |
| |
| 作者姓名： | 杨钦河 杨环文 谢芳 张玉佩 |
| |
| 作者单位： | 暨南大学医学院中医系,广东,广州,510632 |
| |
| 基金项目： | 广东省科技计划资助项目(2008B030301160) |
| |
| 摘 要： | 目的:观察降脂宁肝胶囊对大鼠脂肪肝的治疗作用并初步探讨其作用机制。方法:以高脂饲料并灌服乙醇6周造成大鼠脂肪肝模型,分为降脂宁肝胶囊高、中、低剂量组、东宝肝泰组、自然恢复组、模型组和正常组等7组,连续给药4周后,检测有关指标。结果:降脂宁肝胶囊组与自然恢复组比较,血液中ALT、CHOL和TG水平均显著降低(P<0.01或P<0.05);肝组织CHOL、TG、MDA、GSH水平均有显著改善(P<0.01或P<0.05),且存在量效关系,高剂量组的作用程度与东宝肝泰组相当;肝脏脂变程度显著减轻(P<0.01)。结论:降脂宁肝胶囊对大鼠脂肪肝有较好的治疗作用,其机制可能与降低血脂及抗脂质过氧化有关。
|
| 关 键 词： | 降脂宁肝胶囊 大鼠 脂肪肝 实验研究 中医药疗法 |
Experimental Study of Jiangzhi Ninggan Capsule on Rats Model with Fatty liver Disease |
| |
| YANG Qin-he,YANG Huan-wen,XIE Fang,ZHANG Yu-pei.Experimental Study of Jiangzhi Ninggan Capsule on Rats Model with Fatty liver Disease[J].Liaoning Journal of Traditional Chinese Medicine,2008,35(9):1420-1422. |
| |
| Authors: | YANG Qin-he YANG Huan-wen XIE Fang ZHANG Yu-pei |
| |
| Abstract: | Objective: To observe the therapeutical effect of Jiangzhi Ninggan capsule on rats with fatty liver disease,and to explore the mechanism of it.Methods: The rat models with fatty liver disease were established by feeding on high fat diet combined with ethanol via gavage for 6 weeks.Then the rats were random divided into seven groups:Jiangzhi Ninggan capsule groups(high dose,middle dose,low dose),Dongbao Gantai pill group,natural recovery group,model group and control group.4 weeks later,Liver pathologic chan... |
| |
| Keywords: | Jiangzhi Ninggan capsule rats fatty liver disease experimental study treatment of TCM |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
