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| m6A甲基化修饰在胃癌中的研究进展 | |
| 引用本文： | 贾丽娟,张云强,张百红,岳红云. m6A甲基化修饰在胃癌中的研究进展[J]. 中国肿瘤临床, 2021, 48(18): 950-957. DOI: 10.12354/j.issn.1000-8179.2021.20210672 |
| 作者姓名： | 贾丽娟 张云强 张百红 岳红云 |
| 作者单位： | 1.甘肃中医药大学第一临床医学院 （兰州市730000） |
| 摘 要： | N6-甲基腺苷（N6-methyladenosine，m6A）甲基化修饰是真核细胞mRNA最常见的一种表观遗传修饰方式。m6A甲基化修饰通过调控修饰mRNA，广泛参与细胞内RNA的许多生物学行为，从而影响疾病进展与肿瘤的发生。m6A RNA修饰相关因子在胃癌（gastric cancer，GC）中的异常表达，引发 m6A甲基化修饰失调，影响GC的增殖、转移与侵袭、凋亡和耐药等生物学过程。因此，本文就m6A RNA甲基化修饰在GC发生发展中的作用以及化疗耐药予以综述。 |
| 关 键 词： | RNA m6A甲基化 胃癌 m6A 甲基转移酶 m6A 去甲基转移酶 m6A识别蛋白 |
| 收稿时间： | 2021-04-23 |
Research progress on the role of m6A methylation in gastric cancer |
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| Affiliation: | 1.The First Clinical Medicine College of Gansu University of Chinese Medicine, Lanzhou 730000, China2.Departmengt of Oncology, The 940th Hospital of Joint Logistics Support Force of People’s Liberation Army, Lanzhou 730050, China3.Departmengt of Ophthalmology, The 940th Hospital of Joint Logistics Support Force of People’s Liberation Army, Lanzhou 730050, China4.Second Department of General Surgery, Gansu Provincial People's Hospital, Lanzhou 730000, China |
| Abstract: | N6-methyladenosine (m6A) modification are one of the most common epigenetic modifications found in eukaryotic mRNA, and it is known to affect several biological processes. It mainly affects the intracellular RNA levels via modification of mRNA in the cell, and these changes can play a key role in disease progression and tumorigenesis. In recent years, many studies have found that m6A RNA modification related factors are abnormally expressed in gastric cancers. The m6A modifications result in increased proliferation, risk of metastasis and invasion, apoptosis as well as drug resistance of gastric cancer cells. In this study, we systematically review the diverse role of m6A modifications in the pathogenesis and chemotherapy resistance of gastric cancer. |
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