| 三羧酸循环的代谢物与肿瘤发生相关性的研究进展 |
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| 引用本文： | 魏晨,徐瑞华,鞠怀强.三羧酸循环的代谢物与肿瘤发生相关性的研究进展[J].中国肿瘤临床,2021,48(21):1088-1092. |
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| 作者姓名： | 魏晨 徐瑞华 鞠怀强 |
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| 作者单位： | 中山大学肿瘤防治中心，华南肿瘤学国家重点实验室 （广州市 510060） |
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| 基金项目： | 本文课题受国家自然科学基金优青青年科学基金项目 （编号:82022052）资助 |
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| 摘 要： | 许多与生物能量或生物合成相关的代谢物都可以参与细胞的恶性转化，特别是线粒体三羧酸循环的中间产物，如琥珀酸、延胡索酸、D-2-羟基戊二酸、乙酰CoA和NADPH等，已被证实在肿瘤中发挥非代谢功能。本综述将对这些三羧酸循环中间代谢物与肿瘤发生发展的研究进展进行总结。
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| 关 键 词： | 三羧酸循环 代谢物 肿瘤 |
| 收稿时间： | 2021-05-22 |
Advances in relationship between tricarboxylic acid cycle metabolites and tumor development |
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| Institution: | State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China |
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| Abstract: | Several metabolites associated with bioenergetics and biosynthesis, particularly intermediates from the mitochondrial tricarboxylic acid (TCA) cycle, such as succinate, fumarate, 2-hydroxyglutarate isomers (D-2-hydroxyglutarate and L-2-hydroxyglutarate), acetyl-CoA, and NADH/NADPH, may participate in cell malignant transformation. It has been proven that these metabolites exert “nonmetabolic” signaling functions during tumorigenesis. In this review, we will describe the advances in TCA cycle metabolites and tumor formation. |
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