中西医结合治疗心肾综合征的Meta分析

目的 通过Meta分析评价中西医结合治疗心肾综合征的有效性.方法 检索中国知识基础设施工程(CNKI)、万方数据知识服务平台(Wanfang Data)、维普中文期刊服务平台(VIP)、PubMed和Webofscience数据库,纳入中西医结合治疗心肾综合征的随机对照临床研究,时间从建库截至2021年5月,经筛选后最...

Meta-analysis of Integrated Traditional Chinese and Western Medicine in Treating Cardiorenal Syndrome

Objective:To evaluate the effectiveness of integrated traditional Chinese and western medicine in the treatment of cardiorenal syndrome through meta-analysis.Methods:Databases Chinese Knowledge Infrastructure Engineering(CNKI),WanFang Data Knowledge Service Platform(WanFang Data),VIP Chinese Journal Service Platform(VIP),PubMed and Web of Science were searched from inception to May 2021 for randomized controlled clinical studies of cardiorenal syndrome treated by integrated Chinese and Western medicine.A total of 28 studies were finally included after screening.The bias risk assessment tool of the Cochrane Collaboration was used for literature quality evaluation,and the RevMan 5.3 software was used for Meta analysis.Results:The results of the meta-analysis showed that compared with conventional Western medicine treatment,the treatment of cardiorenal syndrome with integrated Chinese and Western medicine had better effects in improving the total effective rate,increasing LVEF,decreasing LVEDD,NT-BNP or BNP,Scr,BUN,CysC,and improving eGFR and inflammatory response than western medicine alone.Conclusion:Based on the current evidence,adequate application of the theory of syndrome differentiation and the selection of appropriate Chinese medicines can better improve the treatment efficacy of cardiorenal syndrome,but high-quality evidence is still needed for verification.