| 心磷脂与缺血/再灌注损伤 |
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| 引用本文： | 戴玥,曾因明. 心磷脂与缺血/再灌注损伤[J]. 国际麻醉学与复苏杂志, 2007, 28(1): 75-78 |
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| 作者姓名： | 戴玥 曾因明 |
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| 作者单位： | 221002,徐州,江苏省麻醉医学研究所,江苏省麻醉学重点实验室 |
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| 摘 要： | 心磷脂（CL）是维持线粒体能量代谢所必需的一种磷脂，参与了众多重要生理过程。此文对CL的结构、合成和转化；在维持线粒体正常功能中的作用；缺血／再灌注（I／R）损伤中的改变以及和线粒体功能的关系等作了逐一阐述，说明CL与I／R损伤导致的细胞死亡关系密切，CL量或性质的改变在细胞凋亡中处于中心地位。
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| 关 键 词： | 心磷脂 缺血再灌注 细胞凋亡 线粒体 |
Cardiolipin and ischemia/reperfusion injury |
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| DAI Yue,ZENG Yin-ming. Cardiolipin and ischemia/reperfusion injury[J]. international journal of anesthesiology and resuscitation, 2007, 28(1): 75-78 |
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| Authors: | DAI Yue ZENG Yin-ming |
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| Affiliation: | Jiangsu Provincial Institute of Anesthesiology and Key Laboratory of Anesthesiology, Xuzhou 221002, China |
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| Abstract: | Cardiolipin(CL)is an important phospholipid tor energy metabolism of eukayotic mitochondria,mvolved in mito- chondrial electron transportation,ADP/ATP transition,penetration through voltage-dependent anion channel and protein transporta- tion.This review describes CL's structure,synthesis and transition;its key role in maintaining mitochondrial strocture and function; the potential regulatory mechanisms leading to loss of CL during ischemia/reperfusion(I/R);the influence of CL loss on mitochondrial function.As a conclusion,decrease of CL level is closely related to I/R injury-induced cell apoptosis. |
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| Keywords: | cardiolipin ischemia/reperfusion injury cell apoptosis mitochondria |
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