| 多发性硬化患者的认知障碍与磁共振成像和事件相关电位的相关性研究 |
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| 引用本文： | 李莉莉,张星虎. 多发性硬化患者的认知障碍与磁共振成像和事件相关电位的相关性研究[J]. 中国全科医学, 2011, 14(8) |
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| 作者姓名： | 李莉莉 张星虎 |
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| 作者单位： | 1. 北京垂杨柳医院神经内科,北京市,100022
2. 首都医科大学附属北京天坛医院神经内科,北京市,100050 |
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| 摘 要： | 目的 对多发性硬化(multiple sclerosis,MS)患者的认知状态、神经电生理、影像学特点进行综合评价,初步探讨MS患者认知障碍的发生率、特点和发生机制.方法 对28例复发缓解型MS患者进行神经心理评价、事件相关电位(ERP)检查,磁共振成像(MRI)检查.观察MS患者认知障碍发生情况,分析其与ERP及MRI检查异常发现的相关关系.结果 MS患者认知障碍的发生率为71.4%(20/28),其中韦氏成人(或儿童智力)量表测查,全量表智商(FIQ)低于正常(＜90分)者17例(60.7%);临床记忆量表检查,记忆商(MQ)低于正常(＜90分)者18例(64.3%).韦氏智力测查,智力有缺损者与无缺损者的MRI病灶等级评分[分别为(2.5±1.6)分和(1.4±1.5)分]比较,差异无统计学意义(P＞0.05),而临床记忆量表测查病灶等级评分[分别为(2.7±1.3)分和(0.9±1.4)分]、额叶病灶评分[分别为(1.11±0.83)分和(0.40±0.84)分]间差异均有统计学意义(P＜0.05).综合分析有无认知障碍者病灶等级评分间差异有统计学意义(P＜0.05).有认知障碍与无认知障碍者P300潜伏期间差异有统计学意义(P＜0.01).结论 MS患者有较高的认知功能损害发生率,神经功能缺损、病灶等级评分与之相关.ERP检查也是评价认知功能的有效方法.
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| 关 键 词： | 多发性硬化 认知障碍 事件相关电位,P300 磁共振成像 |
The Study of Cognitive Impairment in Patients with Multiple Sclerosis and Its Relationship with MRI and ERP |
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| LI Li-li,ZHANG Xing-hu. The Study of Cognitive Impairment in Patients with Multiple Sclerosis and Its Relationship with MRI and ERP[J]. Chinese General Practice, 2011, 14(8) |
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| Authors: | LI Li-li ZHANG Xing-hu |
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| Affiliation: | LI Li-li,ZHANG Xing-hu.Department of Neurology,Chuiyangliu Hospital in Beijing,Beijing 100022,China |
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| Abstract: | Objective To evaluate the cognitive impairment,results of neuro-electrophysiological and magnetic resonance image(MRI) and to discuss the frequency,characteristic and mechanism of cognition disorder in patients with multiple sclerosis. Methods Twenty-eight patients with remitting-relapsing multiple sclerosis underwent Event-Related Potentials(ERP),MRI scan.Wechsler Intelligence Tests and Clinical Memory Scale were used to assess the degree of cognition and affective disorder.The incidence of cognitive disor... |
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| Keywords: | Multiple sclerosis Cognition disorders Event-related potentials P300 Magnetic resonance imaging |
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