CD3、CD4、COX-2在非小细胞肺癌中的表达及意义

目的:探讨非小细胞肺癌(NSCLC)组织中CD3、CD4及环氧化酶-2(COX-2)的表达及临床意义。方法:用免疫组化法检测37例NSCLC手术标本中CD3、CD4、COX-2的表达情况,用Spearman秩和检验分析它们与患者总生存(OS)间的关系。结果:NSCLC患者组织中CD3平均面密度、CD4平均光密度均与患者OS相关(P<0.05),CD3高表达者OS较长,CD4低表达者OS更长。COX-2表达与患者术后生存时间无关(P>0.05)。结论:CD3表达越强,患者术后OS时间越长;CD4表达越强,患者术后生存时间越短;COX-2的表达强度与患者生存时间无明显相关。

Expression and clinical significance of CD3, CD4 and COX-2 in non-small cell lung cancer

AIM: To study expression and clinical significance of CD3,CD4 and COX-2 in non-small cell lung cancer(NSCLC).METHODS: Expression of COX-2,CD3 and CD4 was detected by immunohistochemical staining in 37 cases of NSCLC.The correlation of CD3,CD4,COX-2 expressions and overall survival(OS) was evaluated with spearman rank correlation analysis.RESULTS: The average surface density of CD3 and the average optical density of CD4 were significantly associated with OS of NSCLC patients after surgery(P<0.05).However,both two densities of COX-2 were correlated with survival time of patients(P>0.05).CONCLUSION: The expressions of CD3,CD4 were significantly associated with OS of NSCLC patients.