Sedative activity of hexane extract of Keampferia galanga L. and its active compounds |
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Authors: | Huang Linfang Yagura Toru Chen Shilin |
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Institution: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100094, China. hlf333333@yahoo.co.jp |
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Abstract: | Ethnopharmacological relevanceIt is well known that fragrance impacts behaviors and autonomic functions, and is increasingly used as relaxant, carminative, as well as sedative in aromatherapy. Kaempferia galanga L. is one of the popular traditional aromatic medicinal plants used in tropics and subtropics of Asia including China, Japan and Indochina.Aim of the studyThe aim of present study was to investigate sedative effects of hexane extract of Kaempferia galanga L.and 2 active aromatic compounds (compound 1: ethyl trans-p-methoxycinnamate and compound 2: ethyl cinnamate ) included in the extyract by means of inhalation in mice.Materials and methodsSedative activity was assessed by inhalation of the hexane extract and two major aromatic compounds.ResultsInhalation of hexane extract at the doses of 1.5 and 10 mg showed significant reduction of locomotor activity, indicating considerable sedative and relaxant effects. Compound 1 and 2 were proved to possess sedative effects at 0.0014 mg and 0.0012 mg respectively.ConclusionsThese results suggest the promising application of Kaempferia galanga L. and its constituents in aromatherapy. |
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Keywords: | Sedative Aromatic compounds Ethyl cinnamate Ethyl trans-p-methoxycinnamate Hexane extract Keampferia galanga L |
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