小青龙汤加减治疗毛细支气管炎痰浊壅肺证随机对照试验

目的 观察小青龙汤加减治疗毛细支气管炎痰浊壅肺证的疗效及安全性。方法 共纳入2012年12月至2015年6月分别在广东省中医院、辽宁中医药大学附属医院住院就诊的毛细支气管炎患儿128例。所有患儿均接受布地奈德和硫酸沙丁胺醇雾化吸入及支持、对症治疗。治疗组患儿在此基础上联用小青龙汤加减。治疗前后分别观察两组患儿症状、体征总积分，比较两组住院时间，监测肝、肾功能和不良事件。结果 治疗组和对照组分别脱落1例和4例。治疗3、5、7 d后，治疗组患儿的症状、体征总积分均明显低于对照组（P<0.05）；治疗7 d后，治疗组患儿的症状、体征总积分下降程度明显大于对照组（P<0.05）；治疗组患儿的住院时间较对照组明显缩短（P<0.05）；南北两地医院治疗组患儿各时点症状、体征总积分比较，差异均无统计学意义（P>0.05）；两组患儿均无肝、肾功能异常及不良事件发生。结论 小青龙汤加减治疗毛细支气管炎痰浊壅肺证可明显缓解临床症状，缩短住院时间，具有较好的安全性。

Efficacy of Modified Xiao-Qing-Long Decoction in Treatment of Bronchiolitis with Syndrome of Turbid Phlegm Obstructing the Lung: A Randomized Controlled Study

Objective To investigate the efficacy and safety of modified Xiao-Qing-Long Decoction in the treatment of bronchiolitis with syndrome of turbid phlegm obstructing the lung. Methods A total of 128 children with bronchiolitis who were hospitalized in the department of pediatrics in Guangdong Hospital of Traditional Chinese Medicine and The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from December 2012 to June 2015 were equally and randomly divided into control group and treatment group. The control group was given Ventolin (2.5 mg) and Pulmicort (1 mg) by aerosol inhalation three times a day, supportive treatment, and symptomatic treatment. The treatment group was given modified Xiao-Qing-Long decoction in addition to the treatment for the control group. Total scores of symptoms and signs, length of hospital stay, liver function, renal function, and adverse events were observed before and after treatment and compared between the two groups. Results One case in the treatment group and four cases in the control group did not complete the treatment. The treatment group had significantly lower total scores of symptoms and signs than the control group after 3, 5, and 7 days of treatment (P<0.05). The treatment group showed significantly greater decreases in total scores of symptoms and signs than the control group after 7 days of treatment (P<0.05). And the length of hospital stay in the treatment group was significantly shorter than that in the control group (P<0.05). In the treatment group, there were no significant differences in total scores of symptoms and signs at different time points between the patients from the two hospitals (P>0.05). No liver dysfunction, renal dysfunction, or other adverse events were observed in both groups. Conclusion Modified Xiao-Qing-Long Decoction can relieve clinical symptoms and shorten the length of hospital stay, and has a good safety in the treatment of bronchiolitis with syndrome of turbid phlegm obstructing the lung.