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| Box-Behnken响应面设计法优化排脓散水提工艺 | |
| 引用本文： | 孙 寒,梁 笑,桂双英. Box-Behnken响应面设计法优化排脓散水提工艺[J]. 安徽中医学院学报, 2018, 37(1): 82-86 |
| 作者姓名： | 孙 寒 梁 笑 桂双英 |
| 作者单位： | 1.安徽中医药大学药学院，安徽 合肥 230012；2.安徽省中医药科学院药物制剂研究所，安徽 合肥 230012；3.新安医学教育部重点实验室，安徽 合肥 230038 |
| 摘 要： | 目的 优选排脓散最佳水提工艺。方法 采用Box-Behnken响应面设计法，以水提液中3个指标性成分（柚皮苷、新橙皮苷、芍药苷）的含量和出膏率的综合评价作为考察指标，考察料液比、浸泡时间、提取时间3个因素对提取工艺的影响。结果 排脓散水提的最佳工艺条件为15倍水，浸泡67 min，提取74 min。结论 Box-Behnken实验设计法优化排脓散的水提工艺方法可行，预测性较好。 |
| 关 键 词： | 排脓散；水提取工艺；Box-Behnken响应面设计法；总评“归一值” |
Optimization of Water Extraction Process for Painong Powder by Box-Behnken Response Surface Methodology |
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| Affiliation: | 1. School of Pharmacy, Anhui University of Chinese Medicine, Anhui Hefei 230012, China; 2. Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Anhui Hefei 230012, China; 3. Key Laboratory of Xin''an Medicine, Ministry of Education, Anhui Hefei 20038, China |
| Abstract: | Objective To investigate the optimal water extraction process for Painong Powder. Methods With the content of three components (naringin, neohesperidin, and paeoniflorin) in water extract and extract yield as the indices of evaluation, Box-Behnken response surface methodology was used to evaluate the effect of solid-liquid ratio, soak time, and extraction time on extraction process. Results The optimal process conditions for water extraction of Painong Powder were 15 times of water, a soak time of 67 minutes, and an extraction time of 74 minutes. Conclusion The water extraction process for Painong Powder optimized by Box-Behnken experimental design is feasible and has good predictability. |
| Keywords: | Painong Powder Water extraction process Box-Behnken response surface Overall desirability |
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