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| 原发性高血压遗传流行病学研究 | |
| 引用本文： | 李学刚. 原发性高血压遗传流行病学研究[J]. 中国优生与遗传杂志, 2009, 17(6): 108-109 |
| 作者姓名： | 李学刚 |
| 作者单位： | 山东省莒南县卫生防疫站,276600 |
| 摘 要： | 目的探讨原发性高血压的遗传模式。方法对117个原发性高血压家系用分离分析法和多基因阈值理论进行遗传模式的研究。结果常染色体显性遗传和隐性遗传模式的统计学检验均具有显著意义（P〈0.05）;资料中子女高血压发病情况分析显示,此病不符合性连锁遗传方式;多基因阈值分析的遗传率为74.83%。结论原发性高血压为多基因遗传疾病,平均遗传度为74.83%±4.28%,对有遗传易感性人群应重点管理,加强防治。 |
| 关 键 词： | 原发性高血压 遗传模式 遗传度 |
A Study on The genetic model of essential hypertension |
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| LI Xue-gang. A Study on The genetic model of essential hypertension[J]. Chinese Journal of Birth Health & Heredity, 2009, 17(6): 108-109 | |
| Authors: | LI Xue-gang |
| Affiliation: | LI Xue - gang. ( Sanitation and Prevention Station of Junan Country , Shandong 276600) |
| Abstract: | Objective ： To investigate the genetic model of essential hypertension. Methods ： Genetic model of essential hypertension was analysed with Segregation analysis and Multi -gene threshold theory in 117 pedigrees. Results Essential hypertension is not suitable for single - gene model, but a multi - gene model. Conclusion： Essential hypertension was of multiple - variant diseases, and the heritability for essential hypertension was 74. 83 ±4. 28%. It suggested that the management and preventive measures must be strengthened in genetic susceptibility group. |
| Keywords: | Essential hypertension Genetic Model Heritability |
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