Murine experimental autoimmune uveoretinitis induced by interphotoreceptor retinoid-binding protein and Klebsiella pneumoniae 03 lipopolysaccharide (K03-LPS): a relation between H-2 haplotype and EAU induction |
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| Authors: | Kazuhiko Ando Joyce Hisae Yamamoto Yujiro Fujino Nobuo Kato Manabu Mochizuki |
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| Institution: | (1) Department of Ophthalmology, Tokyo University School of Medicine, 7-3-1 Hongo, 113 Bunkyo-ku, Tokyo, Japan;(2) Department of Ophthalmology, Tokyo University Branch Hospital, Japan;(3) Department of Bacteriology, Nagoya University School of Medicine, Japan;(4) Department of Ophthalmology, Kurume University School of Medicine, Japan |
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| Abstract: | The pathogenicity of interphotoreceptor retinoid-binding protein (IRBP) in the mouse and H-2 restriction of IRBP-induced experimental autoimmune uveoretinitis (EAU) was tested by repeated immunization using Klebsiella pneumoniae 03 lipopolysaccharide (K03-LPS) as an adjuvant. It was shown that IRBP had a greater capacity to induce EAU than S-antigen. Based on the incidence of EAU induction using B10 congenic mice and other strains, the susceptibility to EAU was, at least in part, controlled by the I-Ak haplotype of the H-2 subregion. The results also indicated that non-major histocompatibility complex (MHC) genes play some role in disease susceptibility. |
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