| 白噪声,脉冲噪声与振动复合因素对耳损伤的实验观察 |
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| 引用本文： | 翟所强 陈洪文. 白噪声,脉冲噪声与振动复合因素对耳损伤的实验观察[J]. 中华创伤杂志, 1994, 10(4): 167-168 |
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| 作者姓名： | 翟所强 陈洪文 |
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| 作者单位： | 中国人民解放军耳鼻咽喉科研究所 |
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| 摘 要： | 用单纯白噪声和脉冲噪声暴露以及白噪声复合脉冲声，稳态噪声、振动、脉冲声复合作用，观察对豚鼠听器的损伤。噪声暴露前、后分别测试各组动物的听性脑干反应阈值。用ＡＢＣ免疫组织化学方法观察各组动物耳蜗肌动蛋白免疫活性。结果白噪声加脉冲声组和振动复合稳态噪声加脉冲声组动物受震前、后阈值比较有差异（Ｐ＜０．０１），而其余各组动物受震后无阈移。上述两组动物耳蜗肌动蛋白免疫活性比对照组和其它组明显减弱。提示复合因素会引起耳损伤，耳蜗内肌动蛋白活性与听阈有一定相关性。因此，在临床上应积极维护耳蜗肌动蛋白活性，以减轻损伤。
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| 关 键 词： | 耳损伤 耳蜗 免疫组织化学 病因 |
Combined Effects of Noise and Impulse and Vibration on the Cochlea of Guinea Pigs |
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| Zhai Suo-qiang,Chen Hong-wen,Wang pei-ying,et al.. Combined Effects of Noise and Impulse and Vibration on the Cochlea of Guinea Pigs[J]. Chinese Journal of Traumatology, 1994, 10(4): 167-168 |
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| Authors: | Zhai Suo-qiang Chen Hong-wen Wang pei-ying et al. |
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| Affiliation: | Zhai Suo-qiang,Chen Hong-wen,Wang pei-ying,et al.Institute of Otolaryngology of PLA,Beijing 100853 |
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| Abstract: | ombined effects of noise and impulse and vibration on cortical response threshold(CRT)and Immunohistochemical activitiesof Actin in the cochlea were studied in 3 0 guinea pigs. The results revea the increase in CRT and decrease in immunohis-tochemical activities of Actin in the animals exposed to combined effects, and there was negative correlation between hearing lossand the Actin immunohistochemical activities. The significances of the results is discussed.(Original article on page 167) |
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| Keywords: | combined effects Acoustictrauma Immunohistochemistry of cochlea |
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