金莲清热泡腾片治疗儿童手足口病(普通型)疗效评价的Meta分析

目的:评价金莲清热泡腾片治疗儿童手足口病的临床疗效与安全性。方法:采用Cochrane系统评价方法,检索Cochrane Library中系统评价资料库和Cochrane临床对照试验中心注册库,荷兰医学文摘数据库(EMbase),美国国家医学检索(Pub Med),中国生物医学文献数据库(CBM),中国期刊全文数据库(CNKI),VIP中文科技期刊数据库,万方数据库,查找有关金莲清热泡腾片治疗手足口病的随机对照试验(RCT),检索时限均从建库至2016年6月。由2名评价者按纳入和排除标准独立筛选文献、提取资料和评价质量后,采用Rev Man 5.2软件进行Meta分析。结果:共纳入8篇文献,共1170例,试验组591例,对照组579例,与对照组相比,金莲清热泡腾片组治疗手足口病有效率高于对照组(OR=5.05,95%CI3.07,8.29]),能有效缩短退热时间(WMD=-51.42,95%CI-58.22,-44.61])及皮疹完全消退时间(WMD=-1.96,95%CI-2.60,-1.33]),差异有统计学意义。结论:金莲清热泡腾片治疗手足口病有一定的优势,但所纳入的文献数量较少,质量相对较差,仍需更多大样本、设计严谨的随机对照临床试验证实。

Meta Analysis of the Efficacy of Jinlian Qingre Effervescent Tablets in the Treatment of Pediatric Hand-Foot-and-Mouth Disease (Ordinary Type)

Objective:To evaluate the clinical efficacy and safety of Jinlian Qingre Effervescent Tablets in the treatment of pediatric hand-foot-and-mouth disease.Methods:Cochrane systematic evaluation method was applied to retrieval the data in Cochrane Library,EMbase,PubMed,CBM,CNKI,VIP and Wanfang Database to search for the random control trials for hand-foot-and-mouth disease during the period from the establishment of the databases to June 2016.Two valuer independently screened the literature,extract data and assessment quality according to the inclusive and exclusive criteria and then analyzed with RevMan 5.2 software.Results:Totally 8 literature with 1170 cases were included,591 cases in experimental group and 579 cases in control group.Compared with control group,the effective rate in Jinlian Qingre Effervescent Tablets group was higher than that in control group (OR =5.05,95％ CI 3.07,8.29]),which can effectively shorten the fever abatement time (WMD =-51.42,95％ CI -58.22,-44.61]) and rash abatement time (WMD =-1.96,95％ CI-2.60,-1.33]);the difference had statistical significance.Conclusion:Jinlian Qingre Effervescent Tablets have certain advantages in the treatment of hand-foot-and-mouth disease.However,the number of included literature was relatively few and the quality was relatively poor.It still needs RCT with large samnles and rigorous design to confirm.