抑癌基因p16在卵巢肿瘤中的表达

目的探讨卵巢癌中抑癌基因p16的表达情况及其与卵巢癌分级分期转移预后的关系.方法用免疫组化ABC法检测30例正常卵巢(NO)、32例卵巢良性肿瘤(BOT)、8例交界性卵巢肿瘤(BLT)和103例卵巢癌(OC)组织中的抑癌基因p16蛋白表达情况.分析p16蛋白表达与卵巢癌分级分期、转移预后的关系.结果①p16蛋白表达在恶性、交界性、良性肿瘤组及止常卵巢中的表达率分别为58.3%、81.3%和26.7%.肿瘤组明显高于正常对照组(P<0.05)、恶性组明显低于良性组(P

PROTEIN EXPRESSION OF PI6 GENE IN OVARIAN CARCINOMA

Objective To study the expression of p16 gene in ovarian tumor and its correlation with the shift of the tumor and its prognosis.Methods Expression of p16 was examined in 30 cases of normal ovarium (NO), 32 benign ovarian tumor (BOT), 8 borderline ovarian tumor (BLT) and 103 ovarian cancer (OC) by using ABC immunohistochemistry. The association between p16 expression and clinicopathology was also analyzed.Results Expression rates of p16 protein in OC, BLT, BOT and NO were 58.3%,81.3% and 26.7% respectively. The expression rate of OC was higher than that of NO. The expression rate of the malignant group was much lower than that of BOT but was higher than that of BLT. P16 expression showed no obvious correlation to the histological types of the tumor, residual size of the tumor, lymphatic node metastasis or the treatment of tumor. The expression percentage of patients in advanced stage with poor differentiation and poor prognosis was significantly decreased.Conclusion P16 gene plays an important role in the incidence and deelopment of ovarian tumor as well as its prognosis.