西酞普兰治疗抑郁症的疗效对照研究

目的 探讨选择性五羟色胺再摄取抑制剂西酞普兰治疗抑郁症的疗效及安全性.方法 将60例符合CCMD-3诊断标准的抑郁症病人随机分为两组,分别给予西酞普兰和阿米替林治疗.疗程6周.采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）评定疗效,并以不良反应量表（TESS）评定不良反应.结果 西酞普兰组显效率为83.33%,阿米替林组为76.67%,差异无显著性.西酞普兰不良反应少而轻微,主要有恶心、口干、头痛.结论 西酞普兰是一见效快、疗效肯定及不良反应少而轻微的抗抑郁药.

A comparative study of the efficacy of citalopram in the treatment of depression

Objective To explore the efficacy and safety of the citalopram in treatment of patients with depression.Methods Sixty patients who met the CCMD-3 criteria of depression were randomly assigned to two groups,one group was treated with citalopram and another with amitriptyline for six weeks.Hamilton Depression Rating Scale (HAMD),Hamilton Anxiety Rating Scale (HAMA) and Treatment Emergent Symptom Scale (TESS) were used to assess efficacy and side effects.Results The significant improvement rate was 83.33% for citalopram group and 76.67% for amitriptyline group after six weeks,but there was no significant difference between the two groups.The side effects of citalopram were lower and lighter than that of amitriptyline.The main side effects of citalopram were nausea,mouth dry and headache.Conclusion Citalopram is an effective antidepressant drug with fewer and lighter side effects,and takes effect rapidly.