Sinusoidal CD30+ diffuse large B‐cell lymphoma can masquerade as anaplastic large cell lymphoma in pediatric posttransplant lymphoproliferative disorders |
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| Authors: | Neel S. Bhatt Michael E. Kelly Bjorn Batdorf Gabriela Gheorghe |
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| Affiliation: | 1. Department of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, Wisconsin;2. Department of Pathology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin |
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| Abstract: | Posttransplant lymphoproliferative disorder (PTLD) is a known complication of solid organ transplantation. Diffuse large B‐cell lymphoma (DLBCL) is frequently seen in this setting. However, CD30+ DLBCL with sinusoidal pattern of involvement has not been reported in pediatric PTLD. We are reporting a 9‐year‐old female child presented with diffuse lymphadenopathy postheart transplantation. The pattern of involvement was suggestive of anaplastic large cell lymphoma, but the malignant cells were positive for B‐cell markers and negative for anaplastic lymphoma kinase. The patient was treated aggressively with multiagent chemotherapy and rituximab. Accurate diagnosis in PTLD is paramount in making management decisions. |
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| Keywords: | diffuse large B‐cell lymphoma posttransplant lymphoproliferative disorder solid organ transplantation |
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