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| 昆明地区吸毒人群和异性性传播HIV-1的分子流行病学 | |
| 引用本文： | 李晓杰,夏雪山,武部豊,草川茂. 昆明地区吸毒人群和异性性传播HIV-1的分子流行病学[J]. 中国皮肤性病学杂志, 2009, 23(5) |
| 作者姓名： | 李晓杰 夏雪山 武部豊 草川茂 |
| 作者单位： | 1. 上海交通大学附属第一人民医院皮肤性病科,上海,200080 2. 昆明理工大学生命科学与技术学院,昆明,650224 3. 日本国立感染症研究所艾滋病研究中心,东京162～8640 |
| 摘 要： | 目的探讨昆明地区吸毒人群和异性性传播感染者HIV-1的分子流行病学特点。方法收集1994~2002年26例昆明地区吸毒人群和异性性传播HIV-1阳性者的血浆,采用BigDye链终止反应试剂盒测定2.6-kb gag-RT区的核苷酸序列,确定HIV-1的基因型分布。结果CRF07_BC和CRF08_BC是吸毒人群中HIV-1的主要基因型;1例吸毒者感染了亚型B′。同样,大多数异性性传播HIV-1感染者的基因型也以CRF07_BC,CRF08_BC和亚型B'为主。结论昆明地区异性性传播HIV-1感染者中流行的病毒基因型来自当地吸毒人群。 |
| 关 键 词： | HIV-1 分子流行病 吸毒人群 异性性传播 |
Molecular Epidemiology of HIV-1 Transmission among Injecting Drug Users and Heterosexuals in Kunming |
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| LI Xiao-jie,XIA Xue-shan,YUTAKA TAKEBE,SHIGERU KUSAGAWA. Molecular Epidemiology of HIV-1 Transmission among Injecting Drug Users and Heterosexuals in Kunming[J]. The Chinese Journal of Dermatovenereology, 2009, 23(5) | |
| Authors: | LI Xiao-jie XIA Xue-shan YUTAKA TAKEBE SHIGERU KUSAGAWA |
| Abstract: | Objective To investigate the molecular epidemiology of HIV-1 among injecting drug users(IDUs) and heterosexuals in Kunming of Yunnan Province.Methods Twenty-six HIV-1 positive plasma samples were obtained from persons in Kunming and environs in1994～2002.The distribution of HIV-1 genotypes was determined based on nucleotide sequences of 2.6-kb gag-RT regions on both strands using BigDye termination reaction kits.Results CRF07_BC and CRF08_BC were the dominant subtypes among IDUs.Subtype B′was found in one IDU.Similarly,a majority of Kunming heterosexuals were infected with CRF07_BC,CRF08_BC or subtype B′.Conclusion The heterosexual HIV-1 epidemic in Kunming appears to derive from the local IDU epidemic. |
| Keywords: | HIV-1 |
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