重症药疹76例临床分析

目的探讨重症药疹的临床特征,分析常见致敏药物、治疗及转归。方法回顾性分析本院2005年8月-2011年3月收治重症药疹的临床资料。结果共收治76例重症药疹。致敏药物:抗微生物类29例(38.16%);生物制品类20例(26.32%);解热镇痛类15例(19.74%);抗痛风类7例(9.21%)。治愈48例,好转25例,死亡3例。结论重症药疹患者应尽早使用足量糖皮质激素并联合静滴免疫球蛋白治疗,同时加强支持疗法,这是稳定病情和降低死亡率的关键。

Clinical Analysis of 76 Cases of Severe Drug Eruption

Objective To study the clinical features,treatment and prognosis of severe drug eruption. Methods A retrospective analysis was carried out on 76 patients with severe drug eruption from 2005 to 2011. Results The causative drugs were antimicrobials (38.16%),biological products(26.32%),antipyretics-analgesic and anti-inflammatory drugs(19.74%),antigout drugs(9.21%),Forty-eight out of 76 patients were cured,25 improved,and 3 died. Conclusion It is important to give sufficient glucoeorticoid earlier combined with intravenous gammagiobulin for the treatment of severe drug eruption, which may be helpful to eontrol the disease and lower the mortality rate.