小儿胃肠功能障碍与胃肠保护

胃肠功能障碍是指胃肠道消化、吸收功能因各种原因受损,表现为胃肠道内细菌异常定植、细菌/内毒素移位、胃肠黏膜屏障损害、免疫紊乱.儿童和新生儿期胃肠功能障碍/衰竭是继发于危重疾病的严重综合征之一,经常是多器官功能障碍综合征的一部分.儿童发育期与成年期肠道在结构和功能上均有明显差别,容易遭受外来感染的打击.胃肠功能障碍的治疗关键是维护肠黏膜屏障,重建肠道的连续性,调整内稳态、循环与氧供,同时积极治疗原发病.

Gastrointestinal dysfunction and gastrointestinal protection in children

Gastrointestinal dysfunction is abnormalities of digestion and absorption caused by various reasons, which manifests bacterial colonization of the gastrointestinal tract, bacterial/endotoxin translocation,gastrointestinal mucosal barrier injury and immune disorders. Child and newborn gastrointestinal dysfunction/failure is secondary to the severe syndrome of critical illness, always be a part of multiple organ dysfunction syndrome. Structure and function of the gastrointestinal tract are significantly different between child and adult. The key therapy strategy of gastrointestinal dysfunction are maintenance of intestinal barrier, reconstruction of intestinal continuity, adjust of homeostasis, circulation and oxygen supply, and management of the primary disease on time.