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| Sonic hedgehog在小鼠胚胎颌面部的表达 | |
| 引用本文： | 杜娟,刘淑红,范文红,沈岩,范志朋,范明,王松灵. Sonic hedgehog在小鼠胚胎颌面部的表达[J]. 北京口腔医学, 2005, 13(1): 6-9 |
| 作者姓名： | 杜娟 刘淑红 范文红 沈岩 范志朋 范明 王松灵 |
| 作者单位： | 1. 首都医科大学2002级博士研究生 2. 军事医学科学院基础所脑保护与可塑性研究实验室 3. 国家人类基因组北方研究中心 4. 100050,北京,首都医科大学口腔医学院基因治疗分子生物学实验室 |
| 基金项目： | 国家高技术研究发展计划(863计划);2002BA711A07-11; |
| 摘 要： | 目的 探讨Sonichedgehog(Shh)在小鼠胚胎颌面部正常发育中的表达。方法 应用免疫组织化学 ABC法和图像分析系统研究Shh在小鼠胚11.5d,13.5d及17.5d颌面部的表达情况。结果 Shh在胚胎11.5d, 13.5d及17.5d的颌面上下颌突均有表达,且较对照组有差异(P<0.05),但在上下颌突之间表达没有差异,在上 皮和结缔组织之间表达基本无差异。结论 Shh在小鼠胚胎颌面部正常发育有明显表达,提示Shh可能参与颌面 部生长发育。 |
| 关 键 词： | 颌面部 表达 下颌突 正常 免疫组织化学ABC法 小鼠胚胎 对照组 发育 上皮 图像分析系统 |
| 文章编号： | 1006-673X(2005)01-0006-04 |
| 修稿时间： | 2004-12-09 |
Expression of Sonic hedgehog in the maxillofacial region of mouse embryo |
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| DU Juan,Liu Shu-hong,FAN Wen-hong,SHEN Yan,FAN Zhi-peng,FAN Ming,WANG Song-ling. Expression of Sonic hedgehog in the maxillofacial region of mouse embryo[J]. Beijing Journal Of Stomatology, 2005, 13(1): 6-9 | |
| Authors: | DU Juan Liu Shu-hong FAN Wen-hong SHEN Yan FAN Zhi-peng FAN Ming WANG Song-ling |
| Abstract: | Objective To observe the expression of Sonic hedgehog(Shh) in the maxillofacial region of mouse embryo. Methods ABC immunocytohistochemistry method and image analysis were used to detect the expression of Shh in maxillofacial region of 11.5-day,13.5-day and 17.5-day mouse embryo. Results The positive expression was found in maxillary and mandibular region in all three stages (P<0.05). No significant difference of expression between maxillary and mandibular region was found. There was no difference of expression between epithelial and connective tissues. Conclusion Shh was positively expressed in maxillofacial region and may be involved in development of this region. |
| Keywords: | Sonic hedgehog Mouse embryo Maxillofacial region Immunohistochemistry Image analysis |
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