肼引发损伤相关小分子代谢物的研究进展

肼是化学合成工业及制药领域的重要中间产物,也是肼类药物的共同代谢产物。肼具有肝、肾、中枢神经等多器官毒性,严重威胁人类健康。随着生命科学技术的发展,代谢组学能够全面、整体地获得机体受到外源性刺激后体内内源性小分子代谢物的扰动信息。代谢组学已用于发现与肼损伤相关的具有特殊生物功能的可能生物标志物。该文总结了近年来基于代谢组学方法对肼引发损伤相关的小分子代谢物的研究进展,以期为肼损伤的机制研究、早期发现及治疗提供研究思路。

Research advances in metabolites related with hydrazine toxicity based on metabonomics

Hydrazine is an important intermediate both in industrial synthetic chemistry and pharmaceutical production.It is also the common metabolite of hydrazine medicine.Hydrazine induces hepatotoxicity,nephrotoxicity and neurotoxicity,which is a severe health menace to human being.As life science develops,metabonomics can obtain global and comprehensive changes of metabolites,response to toxicity.It has been used for revealing the endogenous metabolites disorder after exogenous hydrazine stimulation and finding special biological function of potential biomarkers related to hydrazine.This article focuses on the research progress of metabolites related with hydrazine toxicity based on metabonomics in recent years,which would provide ideas for mechanisms,early discovery and therapy of hydrazine toxicity.