代谢综合征各成分与臂踝脉搏波速度的关系研究

目的:探讨代谢综合征异常各成分与臂踝脉搏波速度(baPWV)的关系.方法:按照2005年国际糖尿病联盟(IDF)代谢综合征诊断标准,将571例研究对象(男269例,女302例,平均年龄56.2岁)分为对照组40例、1项代谢异常组108例、2项代谢异常组154例、3项代谢异常组269例,应用脉搏波速度自动测量系统测定baPWV,并结合各临床观察指标进行分析.结果:简单相关分析结果显示年龄、收缩压、舒张压、空腹血糖、总胆固醇、甘油三酯和腰围与baPWV的相关性有统计学意义(P<0.05).采用多元线性逐步回归方法分析显示年龄、平均动脉压、空腹血糖及甘油三酯与baPWV呈正向独立相关.调整性别和年龄后,baPWV值在对照组13.1 m/s,1项代谢异常组14.5 m/s,2项代谢异常组15.1 m/s,3项代谢异常组15.9 m/s,各组间比较差异均有统计学意义(P<0.05).结论:baPWV在代谢综合征异常者中显著增加,提示代谢综合征异常项目的增加反映动脉僵硬度的指标变化.

Relationship Study Between Metabolic Syndrome and Brachial-Ankle Pulse Wave Velocity

Objective: To study the relationship between metabolic syndrome(MS)and brachial-ankle pulse wave velocity(baPWV). Methods: According to International Diabetes Federation MS definition in 2005,we enrolled 571 subjects in Beijing area including 269 male and 302 female with the mean age of(56.2±9.5)years.The subjects were divided into 4 groups upon MS components.Group1,the patients with 1 metabolic abnormality,n=108,Group2,the patients with 2 metabolic abnormalities,n=154,Group3,the patients with 3 metabolic abnormalities,n=269,and Control group,the subjects without metabolic abnormality,n=40.baPWV was examined by automatic PWV measuring system and the other clinical parameters were analyzed as well. Results: BaPWV was significantly related to age,systolic blood pressure,diastolic blood pressure,fasting blood glucose,triglyceride,total cholesterol and waist circumference,P<0.05 respectively.Stepwise multiple regression analysis indicated that age,mean arterial pressure,fasting blood glucose and triglyceride were positivety and independently associated with BaPWV.With the adjusted age and gender,baPWV value in Control group was 13.1 m/s,in Group1 was 14.5 m/s,in Group 2 was 15.1 m/s,and in Group3 was 15.9 m/s,P<0.05 respectively. Conclusion: baPWV elevates accordingly with the increased metabolic abnormalities which may imply that more MS components could accelerate the development of arterial stiffness in MS patients.