颅脑损伤术后肺部感染的多因素分析

目的：研究分析颅脑损伤术后肺部感染的相关危险因素。方法2008年1月～2013年10月期间收集我院治疗的1121例颅脑损伤手术患者，其中男性642例，女性479例；年龄19～72岁，平均（43.2±15.4）岁。根据是否合并肺部感染分为观察组与对照组，比较分析年龄、肺基础疾病、格拉斯哥昏迷（ GCS）评分、急性肺损伤、昏迷时间、卧床时间等因素。结果观察组年龄、肺基础疾病、GCS评分、急性肺损伤、昏迷时间、卧床时间与对照组相比较，差异均具有统计学意义（ P＜0.05）；但是两组性别比较差异无统计学意义（ P＞0.05）。观察组抗生素、抑酸剂、脱水剂、糖皮质激素等药物应用时间显著高于对照组，差异均具有统计学意义（P＜0.05）；但是观察组接受机械通气治疗的比例高于对照组，亦具有统计学意义（P＜0.05）。结论颅脑损伤术后肺部感染与多种危险因素相关，医护人员应提高认识，从而减少其危险因素，提高患者治疗质量和改善预后。

Multivariate analysis for post-operative pulmonary infection after traumatic brain injury

Objective To study the relative risk factors of post-operative pulmonary infection after cranio-cerebral trauma .Methods Totally 1 121 craniocerebral trauma patients ,who received surgical treatments between Jan.2008 and Oct.2013,were divided into research group and control group depending on the existence of pulmona -ry infection.There were 642 males and 479 females,ranged with an average age of （43.2 ±15.4） years old（age ranged from 19 to 72 years old）.The relative risk factors were analyzed .Results There were significant differ-ences in age ,lung underlying disease ,GCS score ,acute lung injury ,duration of coma and bed time between the two groups（P0.05）. In addition,the application time of antibiotics ,antacid,dehydrating agent ,and glucocorticoid and the application pro-portion of mechanical ventilation indicated statistical differences in comparison to the control group （ P 〈0.05 ） . Conclusion There are multi-risk factors relative to post-operative pulmonary infection after traumatic brain injury . Medical staffs should raise awareness so as to reduce these risk factors and to improve the therapeutic efficacy and prognosis .