Biochemistry of the effects of asiaticoside on human polymorphonuclear leukocytes |
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| Authors: | A Karan P T Ozand |
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| Affiliation: | 1. College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea;2. College of Pharmacy, Dongguk University-Seoul, Goyang, 10326, Republic of Korea;3. Department of Chemistry, Government College of Arts, Science, and Commerce, Sanquelim, Goa, 403505, India;4. Department of Basic Medical Science, Medical College, Taizhou University, Taizhou, China;5. Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Chungcheongbuk-do, Cheongju, 28116, Republic of Korea;1. Department of Bioscience, Graduate School of Life Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama, 700-0005, Japan;2. Lipid Signaling, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan;3. Institute of Microbial Chemistry, Tokyo, 141-0021, Japan |
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| Abstract: | Asiaticoside is found to increase the 14CO2 production from glucose-U-14C both in resting and phagocytizing human polymorphonuclear leukocytes; but does not seem to affect the methylene blue or cyanide stimulated 14CO2 production at one or other of these physiologic states. Inhibition of 14CO2 production by hydrocortisone is increased through asiaticoside, however, especially when leukocyte H2O2production is at its maximum. Asiaticoside also relieved the 2-deoxyglucose inhibition partially, both at rest and during phagocytosis. These findings were interpreted as indications of the possible action of asiaticoside on leukocyte membrane. When compared with the action mechanisms of other membrane-affecting surface active agents, the effects summarized above, could be explained by the saponin-like structure of asiaticoside. |
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