| 水飞蓟宾防止成年大鼠心室颤动的实验研究 |
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| 引用本文： | 狄思懋,梁瑞廉.水飞蓟宾防止成年大鼠心室颤动的实验研究[J].中国心血管杂志,1998,3(4):240-242. |
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| 作者姓名： | 狄思懋 梁瑞廉 |
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| 作者单位： | 上海市第六人民医院 上海市200233
(狄思懋，梁瑞廉，葛兆莺)，上海市第六人民医院 上海市200233(郁晓明) |
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| 摘 要： | 本实验研究水飞蓟宾对大鼠心室颤动的防止作用,结果表明,静脉注射水飞蓟宾(20mg/kg)后大鼠室颤阈明显提高,但对照组无明显变化,结论认为:水飞蓟宾通过升高大鼠室颤阈而对心室颤动具有一定的防止作用.其机理可能与水飞蓟宾抑制钙离子跨细胞膜内流,从而增加心肌细胞膜电稳定性有关.
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| 关 键 词： | 水飞蓟宾 心室颤动 大鼠 |
The experimental study of preventive effect of silybinon the ventricu;ar fibrllation of the adult rats |
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| Shanghai No. people'hospital: Liang rvilian,Ge zhaoying,Di Simao,et al..The experimental study of preventive effect of silybinon the ventricu;ar fibrllation of the adult rats[J].Chinese Journal of Cardiovascular Medicine,1998,3(4):240-242. |
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| Authors: | Shanghai No people'hospital: Liang rvilian Ge zhaoying Di Simao |
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| Institution: | Shanghai No. 6 people'hospital: Liang rvilian,Ge zhaoying,Di Simao,et al. |
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| Abstract: | Thepreventive effect of silybin on the ventricular fibrllation of the adult rats investigated in a randomized ,solvent-controlled experimental study.Ventricular fibrillation threshold (VFT)was assessed by determing the lowest ihtensity(mA) of electrcal current required to induce ventricular fibrillation by electricalstimulation. In protocal, ratsin silybin qroup had a significant trend to increase VFT; whereas rats in solvet-controlled group had no sihnificant change of VFT.These results indicate tha silybin has a potent antifibrillatory action in the model of VFT of rats ,so that it may have a beneficial effect on protection of rat hearts of ventricular fibrllation. The mexhanism of this effect appears to be related to depression of calcium influx through plasma-membrane by silybin. |
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| Keywords: | silybin rat ventricular-fibrillation |
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