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Synthesis of new triazolyl-N,N-Dialkyldithiocarbamates as antifungal agents
Authors:Sumru Ozkirimli  T. Idil Apak  Muammer Kiraz  Yildiz Yegenoglu
Affiliation:Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 34116 Istanbul, Turkey. sozkir@istanbul.edu.tr
Abstract:
N,N-Dialkylditihiocarbamate derivatives have been well known as broad-range fungicides. In this study, the triazole derivatives of ten new N,N-disubstituted dithiocarbamates (3a-j) were synthesized and their structures were identified by spectral and elemental analysis. Results of the antifungal activity studies showed that some of the compounds tested were active against M. canis, M. gypseum, and T. rubrum at the concentration of 12.5 microg/mL when clotrimazol was used as a standard.
Keywords:Triazole derivatives  Dithiocarbamates  Antifungal agents
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