齐多夫定缓释片的制备及体外评价

目的利用亲水性的Eudragit系列高分子物质单用、与疏水性的乙基纤维素合用制备齐多夫定骨架型缓释片。方法确定5个不同的处方，采用湿法制粒法制备骨架片。结果单独使用Eudragit系列产品作辅料，缓释片只能维持6h的药物持续释放，而RLPO、RSPO与乙基纤维素合用后可以维持12h的持续释药。结论齐多夫定缓释片与常规片比较，缓释片可以雏持12h的药物持续释放，这样会产生更好的治疗效果，减轻药物的副作用，大大改善患者依存率。

Preparation of extended-release matrix tablet of zidovudine and evaluation in vitro

Objective To prepare extended-release matrix tablets of zidovudine using hydrophilic Eudragit alone or their combination with hydrophobic ethyl cellulose. Methods Five recipes were determined. Matrix tablets were prepared by wet granulation method. Results The in-vitro drug release study revealed that Eudragit preparation was able to sustain the release only for 6 hours （94%±4. 5%）, while combining Eudragit with ethyl cellulose could sustain the drug release for 12 hours （88%±4.1%）. Conclusion The developed sustained release tablets of zidovudine have better therapeutic effect than the conventional dosage forms, leading to improved efficacy and better patient compliance.