Glycosaminoglycans in the synovial fluids of patients with juvenile rheumatoid arthritis |
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| Authors: | P F Spelling N Heise O M Toledo |
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| Affiliation: | Department of Rheumatology, University of S?o Paulo, School of Medicine, Brazil. |
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| Abstract: | A simple method was used to isolate hyaluronic acid (HA) and sulfated glycosaminoglycans from synovial fluids obtained from children with juvenile rheumatoid arthritis (JRA) and from normal age-matched controls. The bulk of the glycosaminoglycans present in both normal and pathologic synovial fluids consisted of hyaluronic acid and chondroitin 6-sulfate. The diseased synovial fluids showed a sharp decrease in the concentration of glycosaminoglycans when compared with normal controls. These findings are similar to those reported for the synovial fluid of adult patients with rheumatoid arthritis. |
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