阴道炎与HPV感染及宫颈上皮内瘤样变的关系及其机制

已有的研究发现阴道炎与人乳头瘤病毒（HPV）感染及宫颈上皮内瘤样变（CIN）有关。滴虫性阴道炎在HPV阳性者中的检出率明显高于阴性者；外阴阴道假丝酵母菌病和复发性外阴阴道假丝酵母菌病患者的HPV转阴率低于无假丝酵母菌感染者；高危型HPV持续感染的妇女比高危型HPV转阴的妇女更易患细菌性阴道病，且细菌性阴道病与高危型HPV清除延迟有关；细菌性阴道病在CIN患者中的检出率高于健康妇女。研究还发现阴道微生物组成及pH值与HPV感染有关；阴道乳酸杆菌的减少、缺失与HPV感染、CIN及宫颈癌有关。上述这些问题有待进一步研究。

Vaginitis,HPV Infection and Cervical Intraepithelial Neoplasia

It was found that vaginitis was associated with HPV infection and cervical intraepithelial neoplasia（CIN）. The positive rate of trichomonas vaginitis in those HPV-positive patients was significantly higher than that in HPV-negative patients. The HPV clearance rate in both patients with the newly diagnosed vulvovaginal candidiasis and patients with recurrent vulvovaginal candidiasis was lower than that in patients without candida infections. The women with high-risk HPV persistent infections were more likely to have bacterial vaginosis than those with the high-risk HPV clearance，while bacterial vaginosis was related to the delayed clearance of high-risk HPV. The positive rate of bacterial vaginosis in CIN patients was higher than that in health women. It was also found that the HPV infection was related to the microbial constituent and pH value in vagina. The reduction, or absence, of vaginal lactobacilli were associated with HPV infection, CIN and cervical cancer. It is necessary to explore further all of above problems.