突击量氯磷定治疗急性有机磷农药中毒致呼吸肌麻痹76例观察

目的 比较突击量与非突击量氯磷定方案对急性有机磷农药中毒（ＡＯＰＰ）致呼吸肌麻痹（ＲＭＰ）的治疗效果。方法 对７６例ＡＯＰＰ致ＲＭＰ闰人,根据救治时头３ｄ是否应用突击量氯磷定方案或近似突击量氯磷定方案,将病人分为两组。Ａ组３０例,平均年龄２８．９岁。每天氯磷定用量≥１０．０ｇ,平均１１．４ｇ。Ｂ组病人４６例,平均年龄３０．７岁。每天氯磷定用量〈１０．０ｇ,平均６．３ｇ。结果 Ａ组病人自主呼吸恢复时

Comparison on effects between concentrated-dose and non-concentrated-dose pralidoxime chloride on respiratory muscle paralysis in acute organophosphorus pesticide poisoning

OBJECTIVE: To compare the effects between concentrated-dose and non-concentrated-dose pralidoxime chloride on respiratory muscle paralysis(RMP) in acute organophosphorus pesticide poisoning(AOPP). METHODS: 76 cases of RMP due to AOPP were involved in a retrospective study. All the patients were poisoned through ingestion. According to the administered dose of pralidoxime chloride within the first three days after the onset, the patients were divided into two groups: Group A consisted 30 patients; they were given pralidoxime chloride 10.0-25.8 grams (with an average of 11.4 grams) everyday in the first three days after the onset. Group B included 46 patients; the dose of pralidoxime chloride used daily in the first three days ranged from 3.3 to 8.6 grams (average 6.3). RESULTS: The curative rate and the death rate in group A were 73.3% and 26.7% respectively, while those in group B were 21.7% and 78.3% respectively. The curative rate in group A was significantly higher than that in group B (chi 2 = 19.83, P < 0.005). CONCLUSION: Concentrated-dose pralidoxime chloride was more effective than non-concentrated-dose for patients with RMP due to AOPP and this kind of administration could remarkably improve the prognosis in such patients.