中国内地2型糖尿病合并高血压患者微量白蛋白尿检出率调查

目的调查内分泌科及心内科门诊中糖尿病合并高血压患者微量白蛋白尿（MA）检出率。方法多中心连续收集2型糖尿病合并高血压患者共2473例,采用统一调查表记录患者糖尿病、高血压控制情况及相关并发症,测量血压。采用Micral-Ⅱ试纸半定量比色法筛查尿微量白蛋白。结果2型糖尿病合并高血压患者MA的检出率为42．9％,大量白蛋白尿检出率17．0％。多因素回归分析显示,患者年龄、收缩压水平、空腹血糖水平以及BMI与糖尿病合并高血压患者MA的发生独立相关;除上述因素外,尚有糖尿病病程、应用利尿剂与大量白蛋白尿的发生独立相关。结论在2型糖尿病合并高血压患者中MA检出率极高,MA筛查及强力降压治疗甚为重要。

A survey of microalbuminuria prevalence in hypertensive type 2 diabetic patients in mainland China

OBJECTIVE: To determine the prevalence and risk factors of microalbuminuria (MA) in diabetic patients with hypertension in mainland China. METHODS: This cross-sectional study involved 2473 patients enrolled from 42 diabetic and cardiac outpatient clinics. An immunospecific dipstick Micral Test II was used for MA screening and Nephur7 urinary strip for macroalbuminuria. In addition, blood pressure levels were recorded and questionnaire forms were filled out. Chi square and logistic regression analyses were used for statistical analyses. RESULTS: In the study population the prevalence of MA in hypertensive type 2 diabetic patients was 42.9% and that of macroalbuminuria was 17.0%. Logistic regression analysis showed that age, BMI and systolic blood pressure were independently associated with the occurrence of MA, while the duration of type 2 diabetic and diuretics used were independently associated with the occurrence of macroalbuminuria. CONCLUSIONS: It is shown that there is a high prevalence of MA in hypertensive diabetic patients. Screening of MA and lowering of blood pressure should be the important measures for lowering its occurrence.