吸烟和饮酒与颅内肿瘤关系的Meta分析

目的：分析吸烟和饮酒与颅内肿瘤的关系。方法：应用Mantel Haenszel方法计算合并OR值及其95%可信区间；针对不同设计类型和颅内肿瘤的组织学分类进行敏感性分析。结果：有7篇文献（8项研究）符合纳入标准。关于吸烟与颅内肿瘤关系的8项研究，其合并OR值及其95%可信区间为1.10(0.98,1.24),差异无统计学意义；敏感性分析结果与综合分析结果一致。关于饮酒与颅内肿瘤关系的4项研究，其合并OR值及其95%可信区间为0.76(0.62,0.93),差异有统计学意义；但敏感性分析结果与综合分析结果不一致。结论：现有证据尚不能认为吸烟是颅内肿瘤发病的危险因素；饮酒是否是颅内肿瘤的保护性因素尚有待进一步研究。

Meta-analysis on the association of smoking and alcohol consumption with intracranial tumors

Objective: To analyze the association of smoking and alcohol consumption with intracranial tumors.Method: The summary OR and 95% confidence interval were calculated using Mantel-Haenszel method.And sensitivity analyses were performed by different design type and histological categories of intracranial tumors.Results: Seven literatures(from eight studies) were found that met the protocol-specified inclusion criteria.Pooling the data from the 8 studies about association between smoking and intracranial tumors,yielded the summary OR of 1.10(0.98,(1.24)),being a statistically nonsignificant result which was coordinated with the results of sensitivity analyses.Pooling the data from the 4 studies about association between alcohol consumption and intracranial tumors,yielded the summary OR of 0.76((0.62,)0.93),being a statistically significant result.But it was not coordinated with the result of sensitivity analysis.Conclusion: Evidences in existence do not suggest that smoking is a risk factor of intracranial tumors.And further synthetical analyses are needed to analyze whether alcohol consumption is a protective factor of intracranial tumors.