首发精神分裂症患者血清甲状腺激素的变化及相关因素分析

目的:探讨首发精神分裂症患者血清甲状腺激素的变化及相关影响因素。方法:采用化学免疫发光法检测135例首发精神分裂症患者和100例健康对照组的血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)的水平。同时收集患者的一般资料,进行阳性症状量表(SAPS)、阴性症状量表(SANS)的评定。结果:①病例组的血清FT4水平(17.87±3.07 pmol/L)高于对照组(15.96±2.77 pmol/L),差异具有统计学意义(t=4.773,P=0.000)。②病例组不同病程和不同临床分型患者的血清FT3、FT4和TSH水平的差异均无统计学意义(P>0.05)。结论:首发精神分裂症患者存在血清甲状腺激素水平紊乱,与病程、临床症状关系不大,可能是素质指标。

Analysis of thyroid hormone changes and related factors in first-episode schizophrenia patiens

Objective:To explore the changes of thyroid function in patients with first-onset schizophrenia patients and the related factors.Methods:135 cases with schizophrenia(schizophrenia group) and 100 healthy subjects(control group) were recruited for the research.Thyroid functions(FT3,FT4,TSH) were tested by chemiluminescence immunoassay.Schizophrenia group was tested by the self-made general condition questionnaire,the assessment of positive symptoms(SAPS),the assessment of negative symptoms(SANS).Results: 1.The level of FT4 in the schizophrenia group(17.87±3.07 pmol/L)was higher than that of the control group(15.96±2.77 pmol/L)(t =4.773,P=0.000).2.There were no difference about the different courses and different clinical subtypes in the schizophrenia group(P>0.05).Conclusion: Thyroid functions of patients with first-onset schizophrenia were disturbed,without relationship with course and clinical signs,it may be quality mark.