Synthesis of pyrazole-based 1,5-diaryl compounds as potent anti-inflammatory agents |
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| Authors: | Priyanka Shrivastava Praveen Singh Ashish Kumar Tewari |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, 221 005, India
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| Abstract: | Series of 1,5-diaryl pyrazole ester derivatives have been synthesized and found to contain potent inhibitory activity against cyclooxygenase-2 (COX-2) enzyme. The article describes synthesis of the target pyrazole analogs and biological assay using Carrageenan induced rat paw for investigation. |
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