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Antibacterial activity of aminals and hemiaminals of pyrazole and imidazole |
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| Authors: | Simona Lupsor Florin Aonofriesei Mircea Iovu |
| Institution: | 1. Department of Chemistry, Faculty of Physics, Chemistry, Electronics and Petroleum Chemistry, Ovidius University of Constanta, 124, Blvd. Mamaia, 900527, Constanta, Romania 2. Department of Biology-Ecology, Faculty of Natural Sciences and Agricultural Sciences, Ovidius University of Constanta, 1, University Street, 900347, Constanta, Romania 3. Department of Chemistry, Faculty of Pharmacy, Carol Davila University of Bucharest, 6, Traian Vuia Street, 020956, Bucharest, Romania |
| Abstract: | Antibacterial activity of 1,1′-methylenedipyrazole (AM1), 1-hydroxymethylpyrazole (SAM1), 1,1′-methylenediimidazole (AM2), and 1-hydroxymethylimidazole (SAM2) has been tested against reference and clinical strains by both difusimetric and broth dilution methods. Overall, the minimal inhibitory concentrations of tested compounds ranged from 180 to 270?μg/ml, while the minimal bactericidal concentrations were between 360 and 720?μg/ml. Comparative assessment with phenol and formaldehyde shows that AM1, AM2, SAM1, and SAM2 have moderate to good antibacterial activity. |
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