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| 妊娠糖尿病患者子代脂联素水平与胰岛素抵抗的关系 | |
| 引用本文： | 苏珂,龙艳,林枫,李雄,卢艺红,姚军,张华. 妊娠糖尿病患者子代脂联素水平与胰岛素抵抗的关系[J]. 中国妇幼保健, 2010, 25(6) |
| 作者姓名： | 苏珂 龙艳 林枫 李雄 卢艺红 姚军 张华 |
| 作者单位： | 1. 桂林医学院附属医院,广西,桂林,541001 2. 中国人民解放军181医院妇幼中心 |
| 基金项目： | 广西教育厅科研项目〔200810LX460〕; 广西卫生厅科研项目〔Z2008299〕 |
| 摘 要： | 目的:探讨妊娠糖尿病(GDM)患者子代血清脂联素(APN)水平与胰岛素抵抗(IR)之间的关系。方法:检测28例GDM患者新生儿脐静脉血清、1岁儿童空腹静脉血清和20例正常糖耐量妊娠(NGT)者新生儿脐静脉血清、1岁儿童空腹静脉血清APN、胰岛素、血糖、血脂水平和体重、体重指数(BMI)。结果:①GDM组新生儿脐血清APN、胰岛素水平、体重、BMI比NGT组新生儿显著增高(P0.05),血糖比NGT组新生儿低(P0.05);直线相关分析GDM组新生儿APN与IRI、体重、体重指数呈正相关(P0.05)。②GDM组1岁儿童血清APN水平显著低于NGT组(P0.05),GDM组1岁儿童血清胰岛素、体重、BMI较NGT组高(P0.05);TG、LDL-c水平较NGT组高,HDL-c水平较NGT组低,但组间比较差异无统计学意义(P0.05);直线相关分析GDM组APN与IRI、体重、BMI呈负相关(P0.05),与血糖无关,与血脂无显著相关;回归分析结果,进入回归方程的因素有脂联素(t=2.749,P0.05)、BMI(t=3.624,P0.05)。结论:GDM患者子代血清脂联素水平与IR、体重、BMI有密切关系,GDM患者子代可能是代谢紊乱的高危人群,应受关注。 |
| 关 键 词： | 妊娠糖尿病 脂联素 胰岛素抵抗 |
Relationship between adiponectin level and insulin resistance in offsprings of patients with gestational diabetes mellitus |
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| SU Ke,LONG Yan,LIN Feng et al. Relationship between adiponectin level and insulin resistance in offsprings of patients with gestational diabetes mellitus[J]. Maternal and Child Health Care of China, 2010, 25(6) | |
| Authors: | SU Ke LONG Yan LIN Feng et al |
| Affiliation: | SU Ke,LONG Yan,LIN Feng et al.Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi,China |
| Abstract: | Objective:To explore the relationship between adiponectin level and insulin resistance in offsprings of patients with gestational diabetes mellitus(GDM).Methods:The levels of serum adiponectin,insulin,blood glucose and blood lipids of neonatal umbilical serum samples and fasting venous serum samples in infants aged one year old from 28 cases with GDM(GDM group) and 20 pregnant women with normal glucose tolerance(NGT group) were detected,body weight and body mass index(BMI) in the two groups were measured.Re... |
| Keywords: | Gestational diabetes mellitus Adiponectin Insulin resistance |
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