瞬时受体电位通道A1和瞬时受体电位通道M8在冷过敏中的作用

背景 冷过敏是炎性痛和神经病理性疼痛的一个常见症状,其内在机制尚不清楚. 目的 阐明瞬时受体电位通道A1 （transient receptor potential cation channel,subfamily A,member 1,TRPA1）和瞬时受体电位通道M8（transient receptor potential melastatin 8,TRPM8）参与冷过敏的机制. 内容 综述TRPA1和TRPM8的分子结构和门控机制及其在有害的冷、炎性痛和神经病理性疼痛的冷过敏形成、维持中的作用等方面的研究. 趋向 深入研究TRPA1和TRPM8在冷过敏发生中的作用,有助于阐明冷过敏的机制,并为开发拮抗剂提供理论依据.

The role of transient receptor potential cation channel,subfamily A,member 1 and transient receptor potential melastatin 8 in the cold hypersensitivity

Background Cold hypersensitivity is a common symptom of inflammatory pain and neuropathic pain,however,the underlying mechanism of which remains unclear.Objective To explore the roles of transient receptor potential cation channel,subfamily A,member 1（TRPA1） and transient receptor potential melastatin 8（TRPM8） in cold hypersensitivity.Content The previous literatures on the molecular structure and gating mechanism of TRPA1 and TRPM8,the role in cold hypersensitivity in noxious cold,inflammatory pain and neuropathic pain were reviewed.Trend Progress in the study of TRPA1 and TRPM8 in cold hypersensitivity will contribute to clarify the pathogenesis of cold hypersensitivity,and thus to provide theoretical foundation for the discovery of promising antagonists.