脑内铁过载与神经退行性疾病的研究进展

背景 铁是人体内极其重要的微量元素,参与了许多生物大分子的构成和基本的生命活动.人体内有一套精密完善的储存、转运、调控系统来维持铁稳态,当这一复杂的网络系统出现障碍时将会导致铁代谢紊乱. 目的 综述脑内铁过载在神经退行性疾病发生发展中的重要作用. 内容 通过对近年来相关文献的总结,主要对铁的转运相关蛋白、铁稳态的调节系统、转运机制等方面对铁过载的形成及其与神经退行性疾病的关系进行了初步探讨,脑内异常高浓度的铁参与了阿尔茨海默病、帕金森病等多种神经退行性疾病的病理过程. 趋向 脑内铁过载引起神经退行性变的机制正被逐步阐明,但仍有许多问题有待解决.通过利用铁螫合剂来降低脑内铁过载可能是治疗这类疾病的一个潜在靶点.

Research progress in iron overload and neurodegenerative diseases

Background As a crucial trace element in human body,iron is a component of many biological macromolecules and takes part in some basic life events.A sophisticated and sound system including iron storage,transport,regulation and control maintains iron homeostasis in the body.It will lead to iron metabolism disorder when the complex network is in problems.Objective To review the important roles of iron overload in brain during the genesis and development process of neurodegenerative diseases.Content The formation of iron overload in brain and its relationship with neurodegenerative diseases have be discussed by mainly concluding the issues in iron transporters,homeostatic regulatory system and transport mechanism.Aberrant high iron content in brain participates in pathological process of diverse neurodegenerative diseases,such as Alzheimer＆#39;s disease and Parkinson＆#39;s disease.Trend The mechanism of iron overload causing neurodegeneration is being clarifying,but remains many puzzles to be explored.It may become a potential target for neurodegeneration treatment by using iron chelators to reverse iron overload in brain.