神经肽类物质与牙周支持组织及口腔骨修复

背景：随着对牙周病病因学和神经内分泌研究的深入，神经内分泌因素在牙周病发病及组织修复中的作用成为当今研究的热点。目的：综述神经肽类物质对牙周支持组织的生物学作用，及神经损伤后牙周组织变化的情况。方法：以“神经肽，降钙素基因相关肽，P 物质，舒血管肠肽，神经肽 Y 和牙周组织”为中文关键词，以“Neuropeptide，Calcitonin gene related peptide，substance P，vasoactive intestinal peptide，neuropeptide Y，periodontal”为英文关键词，采用计算机检索CNKI数据库、万方数据库和PubMed数据库，选择有关各类神经肽对牙周支持组织影响的文章进行分析。结果与结论：降钙素基因相关肽、P物质、舒血管肠肽、神经肽Y等相关阳性神经纤维广泛分布在牙周支持组织中，当感觉神经受到损伤后肽能神经分布及神经肽的释放发生改变，作用到牙周支持组织内的的靶细胞，在牙槽骨的改建、牙周韧带及牙周组织免疫功能等各方面发挥作用，这表明神经内分泌因素与牙周组织的关系非常密切，但是，这些相关研究多集中在对正畸和骨折动物模型的研究方面，神经肽等神经递质对牙周病的影响及其具体的作用机制还需要进一步探索。

Effect of neuropeptides on periodontium and oral bone repair

BACKGROUND：With the development of researches on periodontal disease etiology and neuroendocrine factors, the role of neuroendocrine factors on the pathogenesis of periodontal disease and tissue restoration has become a hot spot.OBJECTIVE：To summarize the biological effect of neuropeptides on periodontal tissues and the changes of periodontal tissue after nerve injury.METHODS：A computer-based search of articles was performed in CNKI, Wanfang and PubMed databases using the key words of＆quot;neuropeptides, calcitonin gene related peptide, substance P, vasoactive intestinal peptide, neuropeptide Y and periodontal tissue＆quot;in Chinese and English. The included articles focused on the effect of various neuropeptides on periodontal tissue.RESULTS AND CONCLUSION：Calcitonin gene related peptide, substance P, vasoactive intestinal peptide, and neuropeptide Y positive nerve fibers are widely distributed in periodontal support tissues. When sensory nerves are damaged, the target cel s in periodontal tissues are influenced due to changes of nerve fibers distribution and neuropeptide release. They also play a role in the reconstruction of alveolar bone, immune function of periodontal＆amp;nbsp;ligament and periodontal tissue. This evidence shows that neuroendocrine factors are closely linked with periodontal tissue. However, these studies concentrated in the animal models for orthodontic and fracture, the effect of the neurotransmitters such as neuropeptides on periodontal disease and the mechanisms need further exploration.