| 不同布野方法对非小细胞肺癌调强放疗计划的影响 |
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| 引用本文： | 朱正飞,徐志勇,陈兰飞,胡伟刚,樊旼,吴开良,夏冰,傅小龙. 不同布野方法对非小细胞肺癌调强放疗计划的影响[J]. 中华放射医学与防护杂志, 2010, 30(5): 576-579. DOI: 10.3760/cma.j.issn.0254-5098.2010.05.021 |
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| 作者姓名： | 朱正飞 徐志勇 陈兰飞 胡伟刚 樊旼 吴开良 夏冰 傅小龙 |
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| 作者单位： | 复旦大学附属肿瘤医院放疗科复旦大学上海医学院肿瘤学系,上海,200032 |
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| 摘 要： | ![]()
目的 探索非小细胞肺癌(NSCLC)调强放疗(IMRT)计划设计时不同的设野方法对于计划质量的影响。 方法 21例Ⅰ～Ⅲ期NSCLC患者进入本研究。IMRT采用固定野静态调强技术。每例患者采用不同的设野方法共设计3套调强计划,分别为:IMRT-7,使用等角度的7个射野,射野的入射角度分别为0°、51°、102°、153°、204°、255°、306°;IMRT-5,使用等角度的5个射野,射野的入射角度为0°、72°、144°、216°、288°;IMRT-5m,使用不等角度的5个射野,设野的方法为从前述IMRT-7的7个射野中去除2个野(若患者的病灶位于左肺,则去除角度为255°、306°的两野;若病灶位于右肺则去除角度为51°、102°的两野)。IMRT计划设计时正常肺剂量限制取之于同一患者实际治疗采用的3D-CRT计划肺V5～V60。IMRT开始取处方剂量为65 Gy,根据靶区和关键器官剂量要求按每2 Gy一阶梯进行递增或递减,直至获得最佳计划。结果 比较正常肺受量时发现,在V5～V25之间IMRT-5m的值较另两套计划均明显降低;V30～V40间3套计划相互间无明显差异;V45～V60间以IMRT-5计划最差;肺的平均剂量IMRT-5m最低。食管和脊髓的受量,靶区的适形性指数,以及治疗过程机器的总跳数3套计划间差异不明显。心脏V40以IMRT-5m计划的值最低。两两比较时,IMRT-5较IMRT-7明显增加了靶区的异质性指数值,而其他比较无明显差异。相比于3D-CRT,IMRT-7、IMRT-5和IMRT-5m分别可提高靶区剂量(5.1±4.6)Gy、(3.1±5.3)Gy和(5.5±4.8)Gy。结论 对于NSCLC的IMRT计划设计,射野方向是重要因素,调整好设野的方向可以减少照射野数目保证甚至提高IMRT计划的质量。
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| 关 键 词： | 非小细胞肺癌 调强放射治疗 剂量学 设野角度 射野数目 |
| 收稿时间： | 2009-12-11 |
Impact of different beam set-up methods on quality of intensity modulated radiation therapy in non-small cell lung cancer |
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| ZHU Zheng-fei,XU Zhi-yong,CHEN Lan-fei,HU Wei-gang,FAN Min,WU Kai-liang,XIA Bing and FU Xiao-long. Impact of different beam set-up methods on quality of intensity modulated radiation therapy in non-small cell lung cancer[J]. Chinese Journal of Radiological Medicine and Protection, 2010, 30(5): 576-579. DOI: 10.3760/cma.j.issn.0254-5098.2010.05.021 |
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| Authors: | ZHU Zheng-fei XU Zhi-yong CHEN Lan-fei HU Wei-gang FAN Min WU Kai-liang XIA Bing FU Xiao-long |
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| Affiliation: | Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai 200032 China;Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai 200032 China;Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai 200032 China;Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai 200032 China;Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai 200032 China;Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai 200032 China;Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai 200032 China;Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai 200032 China |
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| Abstract: | ![]()
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| Keywords: | Non-small cell lung cancer Intensity modulated radiation therapy Dosimetry Beam angle Beam number |
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