Hirschsprung's Disease: A Viral Etiology? |
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| Authors: | Paul K. H. Tam W. G. V. Quint D. Van Velzen |
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| Affiliation: | a Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, United Kingdomb Department of Molecular Biology, SSDZ Laboratories, Delft, The Netherlandsc Department of Fetal and infant Pathology, University of Liverpool, Liverpool, United Kingdom |
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| Abstract: | ![]()
This study investigates the hypothesis that Hirschspiung's disease (HD), congenital rectal agangliosis, may be etiologically linked to antenatal cytomegalovirus (CMV) infection. Bowel specimens from 72 HD patients, 144 control I infants (Hirschsprung-like symptoms, normal histology), and 36 control 11 infants (deaths from nongastrointestinal causes) were analyzed for CMV genomes by polymerase chain reaction. Positive results were obtained in 6 HD patients (8.8%) and none of the controls. Our findings suggest that antenatal CMV infection, a potentially preventable condition, may be one of the etiological factors in HD. |
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| Keywords: | Hirschsprung's disease congenital intestinal aganglionosis cytomegalovirus polymerase chain reaction |
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