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| 选择性环氧合酶-2抑制剂的研究现状及进展 | |
| 引用本文： | 曾翼,徐进宜,吴晓明,华维一. 选择性环氧合酶-2抑制剂的研究现状及进展[J]. 中国新药杂志, 2006, 15(6): 410-415 |
| 作者姓名： | 曾翼 徐进宜 吴晓明 华维一 |
| 作者单位： | 中国药科大学药物化学教研室,南京,210009 |
| 基金项目： | 教育部优秀青年教师资助计划;国家自然科学基金 |
| 摘 要： | 非甾体抗炎药（NSAIDs）是临床上应用非常广泛的一类药物，但严重的不良反应使其应用受到很大限制。研究已经发现，NSAIDs对炎症的有效治疗源干其对环氧合酶-2（COX-2）的抑制作用。综述了选择性COX-2抑制剂作用的分子基础、构效关系及其目前研究开发的现状和最新进展。 |
| 关 键 词： | 选择性环氧合酶-2抑制剂 非甾体抗炎药 构效关系 |
| 文章编号： | 1003-3734（2006）06-0410-06 |
| 收稿时间： | 2005-11-08 |
| 修稿时间： | 2005-11-08 |
Advances in selective COX-2 inhibitors |
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| ZENG Yi,XU Jin-yi,WU Xiao-ming,HUA Wei-yi. Advances in selective COX-2 inhibitors[J]. Chinese Journal of New Drugs, 2006, 15(6): 410-415 | |
| Authors: | ZENG Yi XU Jin-yi WU Xiao-ming HUA Wei-yi |
| Affiliation: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
| Abstract: | Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed medications. However, part of NSAIDs were limitedly used due to their significant side effects. It has been found that the therapeutic effects of some NSAIDs are associated with the COX-2 inhibition. In this paper, the molecular basis, structure-activity relationships as well as the advances in R&D of selective COX-2 inhibitors were reviewed. |
| Keywords: | selective COX-2 inhibitors nonsteroidal anti-inflammatory drugs (NSAIDs) structure-activity relationships |
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