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HL-A Antigen Changes in Patients Treated with Chloramphenicol |
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| Authors: | A. Ben-David S. Orgad Y. Danon D. Michaeli |
| Affiliation: | Blood Bank –Tissue Typing Laboratory and the Department of Medicine, Sheba Medical Center, Tel-Hashomer, Israel;Department of Pediatrics, Beilinson Medical Center, Petah-Tiqua, Israel;Director Israel Institute for Biological Research, P. O. Box 19, Ness-Ziona, Israel |
| Abstract: | HL–A antigens were determined by the microlymphocytotoxicity test in patients treated with chloramphenicol and compared with appropriate controls. A reversible loss of antigenicity was found to be associated with chloramphenicol treatment. Possible mechanisms of action and clinical implications are discussed. |
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