首页 | 本学科首页   官方微博 | 高级检索  
     


Clinical and genetic aspects of testicular germ cell tumours
Authors:Martijn F. Lutke Holzik  Rolf H. Sijmons  Josette E.H.M. Hoekstra-Weebers  Dirk T. Sleijfer  Harald J. Hoekstra
Affiliation:1.Department of Surgical Oncology,University Medical Center Groningen, University of Groningen,Groningen,The Netherlands;2.Department of Surgery,Medisch Spectrum Twente,Enschede,The Netherlands;3.Department of Genetics,University Medical Center Groningen, University of Groningen,Groningen,The Netherlands;4.Wenckebach Institute,University Medical Center Groningen, University of Groningen,Groningen,The Netherlands;5.Comprehensive Cancer Center North-Netherlands,Groningen,The Netherlands;6.Department of Medical Oncology,University Medical Center Groningen, University of Groningen,Groningen,The Netherlands
Abstract:
In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 15-40 years. Its incidence has increased sharply in recent years. Fortunately, survival of patients with TGCT has improved enormously, which can chiefly be attributed to the cisplatin-based polychemotherapy that was introduced in the nineteen eighties to treat patients with metastasized TGCT. In addition, new strategies have been developed in the surgical approach to metastasized/non-metastasized TGCT and alterations have been made to the radiotherapy technique and radiation dose for seminoma. Family history of TGCT is among the strongest risk factors for this tumour type. Although this fact and others suggest the existence of genetic predisposition to develop TGCT, no germline mutations conferring high risk of developing TGCT have been identified so far. A small deletion, referred to as gr/gr, identified on the Y chromosome is probably associated with only a modest increase in TGCT risk, and linkage of familial TGCT to the Xq27 region has not been confirmed yet. Whether highly penetrant TGCT-predisposing mutations truly exist or familial clustering of TGCT can be explained by combinations of weak predispositions, shared in utero or postnatal risks factors and coincidental somatic mutations is an intriguing puzzle, still waiting to be solved.
Keywords:testicular germ cell tumour   genetics   familial   therapy   review
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号