Association between a variation in the phosphodiesterase 4D gene and bone mineral density期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Association between a variation in the phosphodiesterase 4D gene and bone mineral density

Authors:	Richard?H?Reneland,Steven?Mah,Stefan?Kammerer,Carolyn?R?Hoyal,George?Marnellos,Scott?G?Wilson,Philip?N?Sambrook,Tim?D?Spector,Matthew?R?Nelson,Andreas?Braun author-information" > author-information__contact u-icon-before" > mailto:abraun@sequenom.com" title=" abraun@sequenom.com" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Sequenom, Inc., San Diego, California, USA;(2) Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Perth, Australia;(3) Rheumatology Unit, Royal North Shore Hospital, NSW, Australia;(4) Twin Research & Genetic Epidemiology Unit, St Thomas Hospital, London, UK

Abstract:	Background Fragility fractures caused by osteoporosis are a major cause of morbidity and mortality in aging populations. Bone mineral density (BMD) is a useful surrogate marker for risk of fracture and is a highly heritable trait. The genetic variants underlying this genetic contribution are largely unknown.

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