Quality of weight loss during chemoradioherapy in patients with nasopharyngeal cancers |
| |
| Affiliation: | 1. Service de radiothérapie carcinologique, faculté de médecine, CHU de Habib-Bourguiba, université de Sfax, Sfax, Tunisia;2. Service d’oncologie médicale, faculté de médecine, CHU de Habib-Bourguiba, université de Sfax, Sfax, Tunisia;1. Département de radio-oncologie et Centre de recherche CHU de Québec–université Laval, centre intégré de cancérologie, 2260, boulevard Henri-Bourassa, Québec, QC G1G 5X1, Canada;2. CHU de Québec-université Laval, Research Centre, Québec, Canada;3. CHU de Saint-Etienne, Department of radiotherapy, Saint-Priest-en-Jarez, France;1. Département de radiothérapie, centre Georges-François-Leclerc, 1, rue du Professeur-Marion, 21079 Dijon, France;2. Service de radiothérapie oncologie, institut du cancer de Montpellier (ICM) - Val d’Aurelle, parc Euromédecine, 208, avenue des Apothicaires, 34090 Montpellier, France;3. Département de radiothérapie, institut universitaire du cancer de Toulouse - Oncopole, 1, avenue Irène-Joliot-Curie, 31100 Toulouse, France;4. Département de radiothérapie et de physique médicale, Quantif-Litis EA 4108, centre Henri-Becquerel, 76038 Rouen, France;1. Department of Radiation Oncology, Elazig Fethi Sekin City Hospital, Elazig, Turkey;2. Department of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey;1. Service de radiothérapie oncologique, hôpital de la Pitié-Salpêtrière, Paris, France;2. Service de neurochirurgie, hôpital de la Pitié-Salpêtrière, Paris, France;3. Unité de radiochirurgie gamma-knife, hôpital de la Pitié-Salpêtrière, Paris, France |
| |
| Abstract: | ![]()
PurposeRadiation therapy with chemotherapy (CCR) is currently the gold standard treatment for nasopharyngeal carcinoma (NPC). Anatomical changes are mainly due to weight loss. Our prospective study aimed to evaluate the nutritional status and the quality of weight loss in our patients to adapt the subsequent nutritional management of patients during treatment for NPC.Patients and methodsA prospective, single-center study of 27 patients with non-metastatic NPC treated in our oncology radiotherapy department between August 2020 and March 2021. Data from interrogation, physical examination, and bioelectrical impedancemetry (weight [W], body mass index [BMI], fat index [GI], fat mass [FM], and fat-free mass (FFM]) were collected at the beginning, the mid, and the end of treatment.ResultsWeight loss from mid to end of treatment (median = −4 kg [−9.4; −0.9]) was greater than that from baseline to mid-treatment (median = −2.9 kg [−8.8; 1.8]) (P = 0.016). Weight loss during the entire treatment was −6.2 kg [−15.6; −2.5] (8.4%). The losses of FM were identical between the beginning-mid treatment and the mid-end treatment; they were respectively −1.4 kg [−8.5; 4.2] and −1.4 kg [−8.2; 7.8] (P = 0.4). FFM losses between the mid- and the end of treatment (−2.5 kg [−27.8; 0.5]) were greater than those between baseline and mid-treatment (−1.1 kg [−7.1; 4.7]) (P = 0.014). Median FFM loss during treatment was −3.6 kg [−28.1; 2.6]).ConclusionThe results of our study show that weight loss during CCR for NPC is complex and is not just about loss but about a disruption of body composition. Regular follow-ups by nutritionists are required to prevent denutrition during treatment. |
| |
| Keywords: | Nasopharyngeal Cancer Weight Radiotherapy Nasopharynx Cancer Poids Radiothérapie |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
