| 喉癌组织中VEGF—C和VEGF-D的研究新进展 |
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| 引用本文： | 强化龙,詹晓东. 喉癌组织中VEGF—C和VEGF-D的研究新进展[J]. 解剖与临床, 2009, 14(2): 135-136,139. DOI: 10.3969/j.issn.1673-7163.2009.02.022 |
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| 作者姓名： | 强化龙 詹晓东 |
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| 作者单位： | 蚌埠医学院第一附属医院耳鼻喉科,安徽蚌埠,233003 |
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| 摘 要： | 目的：探讨喉癌中VEGF—C与VEGF—D的表达及其与淋巴转移的关系。方法：搜集整理新近发表的相关文献，进行归纳总结。结果：VEGF—C及VEGF—D在各种肿瘤组织中的表达均显著增高。喉癌中二者的表达高于癌周及正常组织，且有淋巴转移组的表达高于无淋巴转移组。结论：喉癌的淋巴转移和VEGF-C及VEGF-D的表达相关，阻断VEGF—C／VEGF-D／VEGFR-3通路的表达有望成为抗肿瘤淋巴转移的新手段。
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| 关 键 词： | 血管内皮生长因子C 血管内皮生长因子D 喉癌 转移 |
Research Advancement of VEGF-C and VEGF-D in Laryngeal Carcinoma |
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| QIANG Hualong,ZHAN Xiaodong. Research Advancement of VEGF-C and VEGF-D in Laryngeal Carcinoma[J]. Anatomy and Clinics, 2009, 14(2): 135-136,139. DOI: 10.3969/j.issn.1673-7163.2009.02.022 |
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| Authors: | QIANG Hualong ZHAN Xiaodong |
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| Affiliation: | . (Department of Otorhinolaryngology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233003, China) |
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| Abstract: | Objective：To discuss the expression of VEGF-C and VEGF-D in laryngeal carcinoma and explore the relationship between their expressions and lymphatic metastasis . Methods：To collect and sort the pertinent literatures, then put them into induction and summary . Results： The expressions of VEGF-C and VEGF-D were increased in all kinds of tumor, especially in metastatic tumor. The expression in tissues of laryngeal carcinoma was higher than that in the neighbouring and normal tissues. Conclnsions：There is a correlation between lymphatic metastasis of laryngeal carcinoma and expression of VEGF-C and VEGF-D. Blocking signal pathway of VEGF-C/VEGF-D /VEGFR-3 might become a new therapy against lymphatic metastasis of tumor. |
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| Keywords: | Vascular endothelial growth factor C Vascular endothelial growth factor D Laryngeal carcinoma Metastasis |
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