| 盐酸加巴喷丁缓释片的研制 |
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| 引用本文： | 王秀萍. 盐酸加巴喷丁缓释片的研制[J]. 中国药师, 2007, 10(5): 440-442 |
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| 作者姓名： | 王秀萍 |
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| 作者单位： | 华中科技大学附属梨园医院,武汉430077 |
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| 摘 要： | 目的:研制盐酸加巴喷丁缓释片。方法:利用单因素优化设计法优化处方制备工艺,建立HPLC法测定释放度。结果:最佳处方为盐酸加巴喷丁180 mg,K15M型HPMC 150 mg,CMC·Na 50 mg,可压性淀粉20 mg,5%PVP(K25)95%的乙醇溶液适量,0.5%硬脂酸镁作润滑剂。结论:该优选条件制备的加巴喷丁缓释片工艺简单,体外释药具有明显的12 h缓释作用。
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| 关 键 词： | 加巴喷丁 缓释片 |
| 文章编号： | 1008-049X(2007)05-0440-03 |
| 修稿时间： | 2006-11-13 |
Preparation of Gabapentin Hydrochloride Sustained-release Tablets |
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| Wang Xiuping. Preparation of Gabapentin Hydrochloride Sustained-release Tablets[J]. China Pharmacist, 2007, 10(5): 440-442 |
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| Authors: | Wang Xiuping |
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| Affiliation: | Liyuan Hospital of Huazhong Technology and Suence University, Wuhan 430077, China |
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| Abstract: | Objective:To prepare gabapentin sustained-release tablets.Method:The haplo-factor analysis test was used.A meth- od for determination of release was established in vitro and the release rate of gabapentin sustained-release tablets was determined by HPLC.Result:Gabapentin sustained-release tablets was prepared with gabapentin 180 mg,K15M HPMC150 mg,CMC-Na50 mg,amy- lum pregelatinisatum 20 mg,5% PVP(K25)95% and 0.5% magnesium stearate was quantum,the tablet weight was 400 mg.Conclu- sion:The gabapentin sustained-release tablets have a conspicuous sustained effect for 12 h in vitro. |
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| Keywords: | HPLC |
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