雾化吸入布地奈德治疗小儿急性感染性喉炎的临床疗效及安全性评价

目的 探究小儿急性感染性喉炎采用雾化吸入布地奈德混悬液治疗的临床疗效及对白细胞介素-4(IL-4)、白细胞介素-8(IL-8)、γ-干扰素(IFN-γ)和免疫球蛋白E(IgE)水平的影响.方法 选取小儿急性感染性喉炎110例患儿,按入院时间顺序分组,各55例,两组均给予常规对症治疗,对照组加用雾化吸入地塞米松治疗,观察组加用雾化吸入布地奈德混悬液治疗,对比两组临床疗效、症状改善情况以及不良反应情况,并检测对比两组IL-4、IL-8、IFN-γ和IgE水平.结果 治疗后观察组病程持续时间、症状改善情况及住院时间与对照组比较,明显缩短,差异有统计学意义(P<0.05);观察组疗效(96.36%)较对照组(76.36%),优势明显,差异有统计学意义(P<0.01),且两组均未发现明显药物不良反应.结论 小儿急性感染性喉炎采用雾化吸入布地奈德混悬液治疗效果显著,能有效改善患儿临床症状,改善IL-4、IL-8、IFN-γ和IgE水平,且具有较高的安全性,值得推广.

Clinical efficacy of atomizing inhalation of Budesonide suspension therapy and safety evaluation of treatment on children with acute infectious laryngitis

Objective To investigate the clinical curative effect of Budesonide suspension on children acute infectious laryngitis disease through atomization inhalation therapy and the impact on interleukin-4 (IL-4),IL-8,interferon(IFN)and IgE levels during therapy. Methods One hundred and ten children with acute infectious laryngitis during January 2011 to January 2015 in our hospital were ran-domly divided into two groups and given conventional symptomatic treatment.The control group (55 cases)were treated with dexam-ethasone inhalation,while the observation group (55 cases)were treated with Budesonide suspension.We compared clinical curative effect,including remission of symptoms and adverse reaction.The levelsofIL-4,IL-8,IFN-γand Ig E were analyzed.Results Noobvi-ous adverse drug reaction was found in both group.However,compared with control group,the Budesonide suspension treatment im-proved remission of symptoms,shortened disease duration and hospitalization time,which was statistically significant (P<0.05 ).The observation group represented advantage on clinical efficacy,which showed higher clinical efficacy (96.36%)than the control group (76.36%)(P<0.01).Conclusion It is remarkable that utilizing Budesonide suspension atomization inhalation to therapy children acute infectious laryngitis can effectively improve the relief of clinical symptoms,and induce cytokine (IL-4,IL-8 and IFN-γ)and IgE expression level.It also exhibit high security,indicating its worthy in clinical promoting.